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Effect of Soybean Isoflavone on Presenilin-1 Expression in Hippocampus of Rats with Alzheimer's Disease

Bai Mei

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Abstract

Objective:To explore the effect of soybean isoflavone(SIF) on the expression of presenilin protein-1(PS-1) in rats with Alzheimer's disease(AD).Methods:AD rat models were established by unilateral hippocampus injection of Aβ.The changes in learning and memory capability of AD rats were measured by step down test,the expression of PS-1 in hippocampus of rats were measured by immunohistochemical method.Results:Soybean isoflavone(SIF) could improve learning and memory capability of AD rats(P0.01) by step down test,and significantly decrease the expression of PS-1(P0.01) in hippocampus of AD model group.Conclusion:Soybean isoflavone(SIF) can decrease PS-1 expression and improve learning and memory capability of AD rats.

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What this paper is about

Objective:To explore the effect of soybean isoflavone(SIF) on the expression of presenilin protein-1(PS-1) in rats with Alzheimer's disease(AD).Methods:AD rat models were established by unilateral hippocampus injection of Aβ.The changes in learning and memory capability of AD rats were measured by step down test,the expression of PS-1 in hippocampus of rats were measured by immunohistochemical method.Results:Soybean isoflavone(SIF) could improve learning and memory capability of AD rats(P0.01) by step down test,and significantly decrease the expression of PS-1(P0.01) in hippocampus of AD model group.Conclusion:Soybean isoflavone(SIF) can decrease PS-1 expression and improve learning and memory capability of AD rats.

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Available abstract

Objective:To explore the effect of soybean isoflavone(SIF) on the expression of presenilin protein-1(PS-1) in rats with Alzheimer's disease(AD).Methods:AD rat models were established by unilateral hippocampus injection of Aβ.The changes in learning and memory capability of AD rats were measured by step down test,the expression of PS-1 in hippocampus of rats were measured by immunohistochemical method.Results:Soybean isoflavone(SIF) could improve learning and memory capability of AD rats(P0.01) by step down test,and significantly decrease the expression of PS-1(P0.01) in hippocampus of AD model group.Conclusion:Soybean isoflavone(SIF) can decrease PS-1 expression and improve learning and memory capability of AD rats.

Key concepts: Hippocampus, Presenilin, Immunohistochemistry, Disease, Alzheimer's disease, Internal medicine, Endocrinology, Chemistry

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Effect of Soybean Isoflavone on Presenilin-1 Expression in Hippocampus of Rats with Alzheimer's Disease — Research Paper | ScholarLens