Health Economics Analysis of Comprehensive Intervention in Blocking the Mother-to-Child Transmission of HBV

Objective To explore the effect of comprehensive intervention in blocking the mother-to-child transmission of hepatitis B virus(HBV)and its health economic results.Methods Totally 128 cases of hepatitis B surface antigen(HBsAg),hepatitis B e-antigen(HBeAg)and antibody to hepatitis B core antigen(HBcAb)-positive and 49 cases of HBsAg,antibody to hepatitis B e-antigen(HBeAb)and HBcAb-positive mothers and their children were divided into two groups,who were respectively given two different blocking ways of Hepatitis B immune globulin(HBIG)and hepatitis B Vaccine.The umbilical cord blood of newborn in cord was sampled to observe the intrauterine infection;and as the infants grew to be one year HBV level in venous blood was tested to compare the immune blocking effects.After that,167 cases with effected immune blocking were divided into two groups:intervention group receiving no breastfeeding,but health education and maintenance of antibody to HBsAg;control group receiving breastfeeding,but with no behavior intervention.The serological markers of HBV were detected in the venous blood of the babies when they were three years old.A cost-benefit analysis was conducted.The expected mothers and their newborns infected with HBV in Nanchang in 2005 were taken as the cost study subjects,and the newly discovered hepatitis B patients as benefit study subjects;the cost-benefit ratio after practiced the interventions was calculated.Results There was significant difference in HBV's intrauterine infection rate between two different immune blocking ways in the pregnant women with positive HBsAg,HBeAg and HBcAb(P0.05),but no significant difference in rate of immune blocking(P0.05).In serological markers of HBV detected in the veins blood of the three-year-old babies:there is no case of positive HBsAg in the intervention group,while tone case of positive HBsAg in the control Group.It is expected that,in the 5347 babies whose mother was infected with HBV,the reduced cases with positive HBsAg,acute hepatitis B,chronic hepatitis B,hepatic cirrhosis and hepatic cancer could respectively be 2139,214,214,21 and 2 as the result of conducting the comprehensive intervention of blocking the Mother-to-child transmission of HBV in Nanchang in 2005.The total benefit was 9 843 720 RMB yuan,the total cost was 3 566 448 RMB yuan and the BCR is 2.76.Conclusion The comprehensive intervention can lower the HBV,intrauterine infection,enhance and consolidate the effects of immune blocking,improve the quality of population and produce social and economic benefits greatly.