Analysis of screening results to 9969 women at second trimester pregnancy

Objective:To analyze the change regularity of maternal serum alpha-fetoprotein(AFP),human chorionic gonadotropin(HCG) and non-conpled estriol(uE3) levels among women at second trimester of pregnancy and values of screening.Methods: Time-resolved fluoroimmunoassay was used to test the serum levels of AFP,HCG,uE3,assessment of the risk was conducted by risk2T software,joined factors such as age,weight and gestational weeks etc.The serum levels of AFP,HCG,uE3 both high and low risk at the same gestational weeks were statisticsed and analyzed.High risk pregnancies would be further diagnosed.Results: The serum levels of AFP and uE3 in low risk pregnancies were direct ratio with gestational weeks,while the serum levels of HCG were opposite.the serum levels of AFP and uE3 in Down syndrome were apparently lower than those in low risk pregnancies(P0.01);while levels of HCG were adverse(P0.01).The serum levels of AFP and HCG in trisomy 18 syndrome were significantly lower than those in low risk pregnancies(P0.01).288 of screening pregnancies were detected to be suspect,19of them were diagnosed as followings: down syndrome 6,trisomy 18 syndrome 2,NTD 3 and others 8.Conclusion:the serum levels of AFP,HCG,uE3 of women at second trimester regularly change,to test it can detect Down syndrome,trisomy 18 syndrome and other defective embryo.So screening can greatly reduce birth defective ratio.