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2011•Traditional Chinese Drug Research and Clinical PharmacologyRequires access

Study on Quality Control of Gualougen Capsules

LA Wan-ying

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Abstract

Objective To establish the quality standard of Gualougen Capsules.Methods Radix Trichosanthis,Rhizoma Coptidis,Rhizoma Anemarrhenae and Radix Ophiopogonis were identified by TLC.The content of berberine was determined by HPLC.Zorbox SB C18(150 mm×4.6 mm,5 μm) was used as chromatographic column.Mobile phase consisted of acetonitrili-0.05 mol / L potassium dihydrogen phosphate(22 ∶ 78).The detection wavelength was at 350 nm.The flow rate was 1.0 mL / min.and the temperature of column was set at 25 ℃.Results The result of TLC showed the herbal material was well separated without interference.The linearity of berberine was good in the range of 1.0～25 μg/mL.The average recovery of berberine was 98.26 %,and RSE=1.69 %.Conclusion The method is simple,reliable,and accurate,and can be applied as the quantity control method of Gualougen Capsules.

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Objective To establish the quality standard of Gualougen Capsules.Methods Radix Trichosanthis,Rhizoma Coptidis,Rhizoma Anemarrhenae and Radix Ophiopogonis were identified by TLC.The content of berberine was determined by HPLC.Zorbox SB C18(150 mm×4.6 mm,5 μm) was used as chromatographic column.Mobile phase consisted of acetonitrili-0.05 mol / L potassium dihydrogen phosphate(22 ∶ 78).The detection wavelength was at 350 nm.The flow rate was 1.0 mL / min.and the temperature of column was set at 25 ℃.Results The result of TLC showed the herbal material was well separated without interference.The linearity of berberine was good in the range of 1.0～25 μg/mL.The average recovery of berberine was 98.26 %,and RSE=1.69 %.Conclusion The method is simple,reliable,and accurate,and can be applied as the quantity control method of Gualougen Capsules.

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Available abstract

Objective To establish the quality standard of Gualougen Capsules.Methods Radix Trichosanthis,Rhizoma Coptidis,Rhizoma Anemarrhenae and Radix Ophiopogonis were identified by TLC.The content of berberine was determined by HPLC.Zorbox SB C18(150 mm×4.6 mm,5 μm) was used as chromatographic column.Mobile phase consisted of acetonitrili-0.05 mol / L potassium dihydrogen phosphate(22 ∶ 78).The detection wavelength was at 350 nm.The flow rate was 1.0 mL / min.and the temperature of column was set at 25 ℃.Results The result of TLC showed the herbal material was well separated without interference.The linearity of berberine was good in the range of 1.0～25 μg/mL.The average recovery of berberine was 98.26 %,and RSE=1.69 %.Conclusion The method is simple,reliable,and accurate,and can be applied as the quantity control method of Gualougen Capsules.

Key concepts: Berberine, Chromatography, Radix (gastropod), Quality standard, Chemistry, High-performance liquid chromatography, Potassium, Berberine hydrochloride

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