Expression of VEGF,nuclear EGFR and CD105 in early stage non-small cell lung cancer

Objective To detect the expressions of vascular endothelial growth factor(VEGF),nuclear epidermal growth factor receptor(EGFR)and CD105in the early non-small cell lung cancer and analyze the relationship of these indices with the clinicopathologic features of early stage NSCLC.Methods The expression status of VEGF,nuclear EGFR and CD105 were examined by immunohistochemistric method(IHC)in 30cases of early-stage non-small cell lung cancer and adjacent normal tissue.Results The positive rates of VEGF of 30patients with early stage non-small cell lung cancer and adjacent normal tissue were 53.5%and 26.7%respectively,and the difference was statistically significant(P0.05).The positive rates of nuclear EGFR of 30patients with early stage non-small cell lung cancer and adjacent normal tissue were 16.7% and 0% respectively,and the difference was not statistically significant(P 0.05). MVD marked by CD105of 30patients with early stage non-small cell lung cancer and adjacent normal tissue were(17.3±5.6)and(8.9±4.2)in the adjacent tissues and normal tissues,and the difference was statistically significant(P 0.05).The expression of VEGF and nuclear EGFR were significantly correlated with tumor recurrence and metastasis(r=0.516,P =0.004);The expression of VEGF and nucleus EGFR,as well as the expression of nucleus EGFR and MVD were not significantly correlated(P 0.05). Conclusion The expressions of VEGF,nuclear EGFR and CD105played an important role in the development of early-stage non-small cell lung cancer,and the expressions of VEGF and nuclear EGFR were relevant to the recurrence of early-stage non-small cell lung cancer.