Clinical analysis of secondary pulmonary fungal infection in patients with chronic obstructive pulmonary disease

Objective To investigate the clinical characteristics of secondary pulmonary fungal infection in chronic obstructive pulmonary disease(COPD) patients.Method A total of 199 cases were analysed retrospectively of COPD with secondary pulmonary fungal infection from Jan.2008 to Dec.2010 in our hospital,and the resistance rates were compared.Result Among the 199 cases,candida albicans in 137 cases(68.84%),candida glabrata in 32 cases(8.54%),candida tropicalis in 17 cases(8.54%),candida krusei in 9 cases(4.52%),mucor in 3 cases(1.51%),other candida in 1 case(0.50%),were detected.The detection rates of candida albicans tend to decline,and that of candida tropicalis tend to rise.196 cases of fungus were performed drug sensitivity test,and then the resistance rate to voriconazole,fluconazole,amphotericin B,itraconazole and 5-flucytosine were 3.6%,5.1%,1.0%,8.7% and 0,respectively.However,the drug resistance change showed no significant difference in candida albicans and candida glabrata between 2008 and 2010.Conclusion Candida albicans is still the major pathogenic bacterium in patients with COPD and secondary pulmonary fungal infection,followed by candida glabrata and candida tropicalis.The drug resistance of candida albicans and candida glabrata did not change obviously.