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2006•The Journal of Medical Theory and PracticeRequires access

Therapeutic Effect of Donepezil on Vascular Dementia

Xiaoxi Zhuang

Open publisher page 1 citations

Abstract

Objective:To observe the efficacy and safety of donepezil in treatment of vascular dementia(VaD).Methods:The self-matched method was adopted.36 patients with VaD were give orally donepezil for 12 weeks.The efficacies were assessed with MMSE ADL,and the safety after the treatment was also assessed.Results:The score of MMSE increased 3.6 points,while that of ADL decreased 7.3 points after treatment with donepezil for 12 weeks,the differences were significant.There were 3 patients(8.33%) showing mild side-effect which was temporary phenomenon.Conclusion: It is effective and safe to treat patients with VaD.

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What this paper is about

Objective:To observe the efficacy and safety of donepezil in treatment of vascular dementia(VaD).Methods:The self-matched method was adopted.36 patients with VaD were give orally donepezil for 12 weeks.The efficacies were assessed with MMSE ADL,and the safety after the treatment was also assessed.Results:The score of MMSE increased 3.6 points,while that of ADL decreased 7.3 points after treatment with donepezil for 12 weeks,the differences were significant.There were 3 patients(8.33%) showing mild side-effect which was temporary phenomenon.Conclusion: It is effective and safe to treat patients with VaD.

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Available abstract

Objective:To observe the efficacy and safety of donepezil in treatment of vascular dementia(VaD).Methods:The self-matched method was adopted.36 patients with VaD were give orally donepezil for 12 weeks.The efficacies were assessed with MMSE ADL,and the safety after the treatment was also assessed.Results:The score of MMSE increased 3.6 points,while that of ADL decreased 7.3 points after treatment with donepezil for 12 weeks,the differences were significant.There were 3 patients(8.33%) showing mild side-effect which was temporary phenomenon.Conclusion: It is effective and safe to treat patients with VaD.

Key concepts: Donepezil, Medicine, Vascular dementia, Dementia, Internal medicine, Safety profile, Anesthesia, Adverse effect

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