Adenosine Deaminase in Malignant Pleural Effusion and Tuberculous Pleuritis Clinical Contrast Analysis

Objective: To explore the regular of adenosine deaminase content in tuberculous pleural effusion and malignant pleural effusion. Methods: From March 2010 to May 2012,chest cardiac pleural effusion patients in our hospital were Retrospectively analyzed.The pleural effusion by puncture was determined by colorimetric method of adenosine deaminase levels. Measurement of serum adenosine deaminase levels were compared. Results: Tuberculous pleurisy group of patients with pleural effusion ADA measurement value was89.67, 47, 85 iu/L, cancerous pleural effusion group level was 24. 56×11. 49 iu/L, pleural effusion ADA levels with cancerous pleural effusion in tuberculous pleurisy there was significant difference between groups(P 0.05); to ADA _45 IU/L diagnosis of tuberculous pleurisy: sensitivity to 94.1(48/51), specificity of 88.9%(48/52), with ADA 45 IU/L a diagnosis of malignant pleural effusion: the sensitivity(89.4%(51/55), specificity of 94.4%(51/54), pleural effusion in tuberculous pleurisy ADA/serum ADA ratio 2.25 and 0.72, cancerous pleural effusion group level was 0.43 and 0.1, tuberculous pleurisy and there was significant difference between cancerous pleural effusion group(P 0.05); to ADA in pleural effusion ADA/serum ratio 1.0 was bounded in the diagnosis of tuberculous pleurisy: sensitivity to 90.1(46/51), specificity(45/55) for 81.8. %, ADA/serum ADA in pleural effusion ratio 1.0 in the diagnosis of malignant pleural effusion: sensitivity 82.4%(47/57), specificity(88.7%(47/53)). Conclusion: The content of adenosine deaminase in malignant pleural effusion and tuberculous pleurisy have obvious difference.