Intervention of phosphocreatinase to myocardial damage after PCI in patients with effort angina

Objective To review the influence of exogenous phosphocreatinase on myocardial damage after percutaneous coronary intervention(PCI).Methods The patients with effort angina(n=206) accepted PCI were chosen and randomly divided into two groups(each n=103).The control group was given routine treatment and experimental group,intravenous drip of phosphocreatinase(2 g once and twice a day for 3 days) besides of routine treatment immediately after PCI.The concentration of creatin kinase MB(CK-MB) and treponin I(TnI) were detected in all patients before PCI and 3 days after PCI and the treatment of phosphocreatinase were finished.Results The concentration of CK-MB(82.1±59.0 U/L vs.55.4±40.8 U/L,P=0.01) and TnI(0.483±0.402 μg/ml vs.0.388±0.415 μg/ml,P=0.02) increased significantly in the experimental group compared with the control group after PCI.Conclusion The immediate exogenous phosphocreatinase given to the patients with effort angina can abate myocardial damage after PCI.