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Inhibition mechanism of sodium selenite on SW-111C cells

Yan-Jun Xue

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Abstract

Objective:To investigate the inhibition mechanism of sodium selenite on SW-111C cells.Methods: The apoptosis of SW-111C cells treated with sodium selenite was observed by TUNEL.The expression of p16,p21,PCNA,CD44 treated with sodium selenite was performed by immunohistochemistry technique.The T-lymphocyte subsets were detected by animal experiment. Results: The apoptotic index of SW-111C cells increased and was positively correlated to the concentration of sodium selenite(P0.01).The expression of p16 and p21 was up-regulated and the expression of PCNA and CD44 was down regulated after treated by sodium selenite.After exposure to sodium selenite,the number of CD3+ and CD4+ cells in mice increased and CD4+/CD8+ increased too(P0.05). Conclusion: The sodium selenite could inhibit the proliferation of SW-111C cells by inducing cell apoptosis,and influence the expression of p16,p21,PCNA,CD44 with improving immune function.

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Objective:To investigate the inhibition mechanism of sodium selenite on SW-111C cells.Methods: The apoptosis of SW-111C cells treated with sodium selenite was observed by TUNEL.The expression of p16,p21,PCNA,CD44 treated with sodium selenite was performed by immunohistochemistry technique.The T-lymphocyte subsets were detected by animal experiment. Results: The apoptotic index of SW-111C cells increased and was positively correlated to the concentration of sodium selenite(P0.01).The expression of p16 and p21 was up-regulated and the expression of PCNA and CD44 was down regulated after treated by sodium selenite.After exposure to sodium selenite,the number of CD3+ and CD4+ cells in mice increased and CD4+/CD8+ increased too(P0.05). Conclusion: The sodium selenite could inhibit the proliferation of SW-111C cells by inducing cell apoptosis,and influence the expression of p16,p21,PCNA,CD44 with improving immune function.

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Available abstract

Objective:To investigate the inhibition mechanism of sodium selenite on SW-111C cells.Methods: The apoptosis of SW-111C cells treated with sodium selenite was observed by TUNEL.The expression of p16,p21,PCNA,CD44 treated with sodium selenite was performed by immunohistochemistry technique.The T-lymphocyte subsets were detected by animal experiment. Results: The apoptotic index of SW-111C cells increased and was positively correlated to the concentration of sodium selenite(P0.01).The expression of p16 and p21 was up-regulated and the expression of PCNA and CD44 was down regulated after treated by sodium selenite.After exposure to sodium selenite,the number of CD3+ and CD4+ cells in mice increased and CD4+/CD8+ increased too(P0.05). Conclusion: The sodium selenite could inhibit the proliferation of SW-111C cells by inducing cell apoptosis,and influence the expression of p16,p21,PCNA,CD44 with improving immune function.

Key concepts: Selenium, Proliferating cell nuclear antigen, Apoptosis, TUNEL assay, Sodium, Chemistry, Molecular biology, Cell growth

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