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2011•Unpublished venueRequires access

Effect of Melatonin and Serotonin on Expression of Nitric Oxide Synthase in Cerebral Cortex of Epileptic Rats Induced by Pentylenetetrazole

Limin Liu

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Abstract

Objective To investigate the effect of melatonin and serotonin on expression of nitric oxide synthase(NOS) in cerebral cortex of epileptic rats. Methods The model of epilepsy was induced by melatonin in rats and the expression of NOS in cerebral cortex was detected by western blot analysis.The level of 5-HT in hippocampus was demonstrated with immunohistochemistry.Results The expression of NOS in cerebral cortex of epileptic rats was increased in melatonin group,compared with control group,and there was significant difference(P0.05);Compared with melatonin group,glucocorticoids could significantly decrease the expression of NOS in cerebral cortex(P0.05) Conclusion Melatonin and serotonin have inhibitory effect on the expression of nitric oxide synthase in cerebral cortex of epileptic rats.

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What this paper is about

Objective To investigate the effect of melatonin and serotonin on expression of nitric oxide synthase(NOS) in cerebral cortex of epileptic rats. Methods The model of epilepsy was induced by melatonin in rats and the expression of NOS in cerebral cortex was detected by western blot analysis.The level of 5-HT in hippocampus was demonstrated with immunohistochemistry.Results The expression of NOS in cerebral cortex of epileptic rats was increased in melatonin group,compared with control group,and there was significant difference(P0.05);Compared with melatonin group,glucocorticoids could significantly decrease the expression of NOS in cerebral cortex(P0.05) Conclusion Melatonin and serotonin have inhibitory effect on the expression of nitric oxide synthase in cerebral cortex of epileptic rats.

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Available abstract

Objective To investigate the effect of melatonin and serotonin on expression of nitric oxide synthase(NOS) in cerebral cortex of epileptic rats. Methods The model of epilepsy was induced by melatonin in rats and the expression of NOS in cerebral cortex was detected by western blot analysis.The level of 5-HT in hippocampus was demonstrated with immunohistochemistry.Results The expression of NOS in cerebral cortex of epileptic rats was increased in melatonin group,compared with control group,and there was significant difference(P0.05);Compared with melatonin group,glucocorticoids could significantly decrease the expression of NOS in cerebral cortex(P0.05) Conclusion Melatonin and serotonin have inhibitory effect on the expression of nitric oxide synthase in cerebral cortex of epileptic rats.

Key concepts: Melatonin, Nitric oxide synthase, Cerebral cortex, Internal medicine, Endocrinology, Hippocampus, Serotonin, Nitric oxide

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Effect of Melatonin and Serotonin on Expression of Nitric Oxide Synthase in Cerebral Cortex of Epileptic Rats Induced by Pentylenetetrazole — Research Paper | ScholarLens