2008•Journal of clinical and experimental medicineRequires access
Effect of glucocorticoids on expression of nitric oxide synthase in cerebral cortex of epileptic rats induced by pentylenetetrazole
Dai Ji-bin
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Abstract
Objective To investigate the effect of glucocorticoids on expression of nitric oxide synthase(NOS)in cerebral cortex of epileptic rats.Methods The rat model of epilepsy was induced by pentylenetetrazole and the expression of NOS in cerebral cortex was detected by western blotting.Results The expression of NOS in cerebral cortex of epileptic rats was increased in pentylenetetrazole group,and there was significant difference(P0.05)in comparison with that of control group.Compared with pentylenetetrazole group,the expression of NOS in cerebral cortex(P0.05)could be significantly decreased by glucocorticoids.Conclusion Glucocorticoids have inhibitory effect on the expression of nitric oxide synthase in cerebral cortex of epileptic rats.