No-invasive positive pressure pentilation for chronic obstructive pulmonary disease at acute exacerbation period complicating respiratory failure of type II of sixty five patients

Objective To evaluate the clinical effect of no-invasive positive-pressure ventilation(NIPPV) in treating chronic obstructive pulmonary diseases(COPD) at acute exacerbation period complicating type Ⅱ respiratory failure.Methods One hundred and twenty-seven cases with COPD at acute exacerbation period complicating type Ⅱ respiratory failure were divided into observation group(n=65) and control group(n=62).The control group were given drug treatment;Based on this,NIPPV were given in observation group.The breathing frequency and heart rate before and after treatment were observed between two groups.The arterial blood gas analysis results were collected before and 3 hours,1,3,7 days after the treatment and then were compared between two groups.Results There were no statistic significance of heart rate and breathing frequency before treatment between two groups(P0.05).Compared with before treatment,the heart rate and breathing frequency in the two groups were improved significantly at 3 hours,1,3,7 days after treatment(P0.05).There were statistical significance of heart rate and breathing frequency at 3,7 days after treatment between two groups(P0.05).Before treatment the difference of pH,PaO2 and PaCO2 had no statistical difference between two groups(P0.05).At 3 hours,1,3,7 days after treatment,the pH,PaO2 and PaCO2 were significant improved,and the difference made statistical difference(P0.05).At 1 day and 3 days after treatment the pH was statistically significant difference between two groups(P0.05).At 3 hours,1,3,7 days after treatment the PaO2 and PaCO2 was statistic significance between two groups(P0.05).Conclusion NIPPV has great effects to treat COPD at acute exacerbation complicating type Ⅱ respiratory failure.