Ezrin Protein Non-expression and Prognosis of Patients with Squamous Cell Lung Carcinoma

To investigate the significance of Ezrin protein expression in prognosis of squamous cell lung carcinoma,immunohistochemistry for Ezrin protein was done in 96 patients with squamous cell lung carcinoma.Additionally,the correlation between Ezrin expression and the clinicopathological features of squamous cell lung carcinoma,and the relationship between prognostic factors and patient overall survival was also analyzed.The results showed that,Ezrin protein expression in 40 cases of squamous cell lung carcinoma(41.67%) was significantly lower than that in adjacent normal tissues(91.67%),and Ezrin non-expression rate were positively correlated with tumor size,pathologic stage,and differentiation;Ezrin non-expression rate emerged as a significantly independent hazard factor(HR: 0.292,95%CI: 0.141-0.606,P=0.001) for overall survival in squamous cell lung carcinoma as well as the pathologic stage,and metastasis.Therefore,Ezrin non-expression predicts a poor prognosis in the squamous cell lung carcinoma.