Combined therapy of domperidone and compound digestive enzymes for functional dyspepsia:an analysis of 182 cases

Objective: To study the efficacy and safety of combined therapy of domperidone and compound digestive enzymes for functional dyspepsia.Mathods: Eighty-two patients with functional dyspepsia were randomly grouped into the experimental group(n=91) and the controls(n=91).The patients in the control group were only given domperidone 10 mg 3 times per day 30 min before meals for 4 weeks.The patients in the experimental group were given 1 capsule of compound digestive enzyme 3 times a day 30 min after meals in addition to domperidone 10mg 3 times per day for four weeks.The therapeutic efficacy and side effects were compared between the two groups by chi square test.Results: The general therapeutic efficacy in the experimental group was superior to that of the controls(P0.05).The symptoms of upper abdominal pain,abdominal distention,early satiety and stomach burn in the patients in the experimental group were more improved than those in the control group.The experimental group had shown shorter onset time than the controls.No severe side-effects were found in the both groups.Conclusion: Combined therapy of domperidone and compound digestive enzymes can more significantly improve general efficacy and symptoms in the patients with functional dyspepsia than single use of motility medicine domperidone.