2004Journal of Qilu OncologyRequires access

Advances of relationship between XRCC1 polymorphisms and lung cancer susceptibility

Zhou Bao-sen

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Abstract

XRCC1,a gene directly involved in repair of DNA damage,contains at least three common polymorphisms.It is possible that these polymorphisms may affect DNA repair capacity and efficiency,thus modulate cancer susceptibility.This paper reviews the structure,function of XRCC1 and advances of the relationship between XRCC1 polymorphisms and lung cancer susceptibility.

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What this paper is about

XRCC1,a gene directly involved in repair of DNA damage,contains at least three common polymorphisms.It is possible that these polymorphisms may affect DNA repair capacity and efficiency,thus modulate cancer susceptibility.This paper reviews the structure,function of XRCC1 and advances of the relationship between XRCC1 polymorphisms and lung cancer susceptibility.

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Available abstract

XRCC1,a gene directly involved in repair of DNA damage,contains at least three common polymorphisms.It is possible that these polymorphisms may affect DNA repair capacity and efficiency,thus modulate cancer susceptibility.This paper reviews the structure,function of XRCC1 and advances of the relationship between XRCC1 polymorphisms and lung cancer susceptibility.

Key concepts: XRCC1, Lung cancer, DNA repair, Biology, Genetics, Lung cancer susceptibility, Gene, Genotype

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