Cnilical Study on Chinese Herb Biejiajian Pill for Treating Hepatic Fibrosis

Objective: To study the treating effect of Chinese herbs Biejiajian pill on hepatic fibrosis in chronic hepatitis patients. Methods: Serum hepatic fibrosis marks such as hyaluronic acid (HA)、 procollagen 333333 type (PC Ⅲ) and laminin (LN) were measured with radioimmunoassay (RIA), 80 chronic hepatitis patients with abnomal hepatic fibrosis marks were chosen. These patients were randomly divided into two groups: Biejiajian pill group (n = 40) and control group (n = 40). The control group was given common liver protective drugs. The serum hepatic fibrosis marks and liver histopathological change under microscope were observed after 3 months. Result: The level of serum HA、 PC Ⅲ and LN were significantly lower after treating (87. 2±41. 7ng/ml、126. 7?3. 6μg/L and 43. 4±20. 7ng/ml) than those before treating (465. 3±121. 5ng/ml、 190. 5±77. lμg/L and 164. 7±41. 7ng/ml) in Biejiajian pill group (P0. 01) and closed to healthy people (57. l ±27ng/ml、 83. 5± 17. 8μg/L and 38.2±11.85ng/ml) (P0. 05). There was significant change in serum hepatic fibrosis marks between in Biejiajian pill group(87. 2±41. 7ng/ml, 126. 7 ±53. 7μg/L and 43. 4 ± 20. 7ng/ ml) and in control group(261. 7±105. 3ng/ml, 191. 2±61.3μg/L and 89. 4± 45. 3ng/ml)(P0. 05). Liver histopathological result under microscope showed that the degree of hepatocyte degeneration and hepatic fibrosis were obviously reduced after treating than those before treating in Biejiajian pill group. Conclusion: Chinese herbs Biejiajian pill can effectively treat hepatic fibrosis in chronic hepatitis patients.