Evaluation of Systolic Function of myocardia on Ischemia-reperfusion by Quantitative Tissue Velocity Imaging and Two Dimensional Echocardiography

Objective: To evaluate the myocardial systolic function after acute ischemia and reperfusion by quantitive tissue velocity imaging(QTVI),and provide experimental basis for QTVI in estimating the myocardial function of myocardial ischemia and post-reperfusion in clinic.Methods: All the experimental animals were randomly divided into two groups: control group(Con,n=7) and ischemia postconditioning group(Post-C,n=7).In control group,after the left anterior descending artery(LAD) was occluded for 60 min,the heart was reperfused for 180 min;in ischemic postconditioning group,after 60 min of LAD occlusion,reperfusion was initiated for 30 s followed by 30 s of re-occlusion,repeated for three cycles,reperfusion was continued for a total of 180 min in all experiments.All indexes of systolic function(systolic peak velocity Vs、systolic peak displacement Ds、 and ejective fraction of left ventricle EF)were examined against baseline,at the end of 60 min ischemia and after 180 min reperfusion.Results: the Vs and Ds measured by QTVI were well correlated with EF.Vs、Ds and EF had no significant difference in baseline between the two groups(P0.05),Indexes of systolic function was significantly reduced in the ischemia group(P0.05).At the end of 180 min of reperfusion,compared to the Con group,the indexes were higher in the Post-C group(P0.05).Conclusion: QTVI technique could evaluate systolic function exactly in acute myocardial ischemia-reperfusion injury(MIRI),and is well correlated with 2-DE.