Evaluation of regional wall motion during myocardial ischemia and reperfusion by quantitive tissue velocity imaging

Objective To discuss the feasibility of quantitive tissue velocity imaging(QTVI) to quantify regional myocardial dysfunction induced by acute ischemia and reperfusion.The results derived from this study provide experimental foundation for QTVI in estimating the segment of myocardial ischemia and evaluating viable myocaridium after reperfusion.Methods Note the peak velocity of the systolic wave(Vs) and the peak velocity of the early diastolic wave(Ve) of regional wall segments of seven dogs with left anterior descending coronary artery(LAD) ligated under the different examination time points(i.e.,pre ligation,basic state;post ligation 5 min,15 min,30 min,60 min,120 min and reperfusion) by using QTVI technique.Postoperation, the myocardial specimen was stained by 1% triphenylatetrazolium chlorde(TTC) solution and tissue structure was analyzed by transmissible electrical microscope to identify whether myocardium was necrosis or not.Results Vs,Ve of every segmental myocardium of the dogs at ligation 5 min,10 min falled evidently in comparison with the basic state of the dogs (P 0.05 ).After the ligation Vs begian to come back 30 min later,while Ve came back slower;Vs and Ve also had a quick tendence of recovery after reperfusion,but lower than those of the basic state.Conclusions QTVI could quantify regional wall motion abnormalities(regional myocardial dysfunction) during myocardial ischemia and reperfusion.And QTVI is useful for clinical diagnosis and treatment of decision making on acute myocardial ischemia.