Clinical application value of serum thyrotrophin receptor antibody(TRAb) in diagnosis of Graves disease

Objective: To approach clinical application value of serum thyrotrophin receptor antibody( TRAb) in diagnosis of Graves disease. Methods: In this text,radio immunoassay( RIA) was taken to detect serum TRAb and chemiluminescence assay was taken to detect the content of serum sTSH,FT3,FT4. The 71 Graves disease patients were divided to pretherapy patients and post-treatment 6months patients,pretherapy patients and post-treatment 24 months patients. The variation of contents of serum TRAb and sTSH,FT3,FT4 between two groups and 40 healthy control group was compared. Results: The serum TRAb level and masculine rate of pretherapy patients were obviously higher than the control group. The difference had significance( P 0. 05); The serum TRAb level and masculine rate of post-treatment patients were obviously lower than pretherapy patients. The difference had significance( P 0. 05). But the serum TRAb level and masculine rate of post-treatment patients were also higher than the control group. The difference had significance( P 0. 05). The serum TRAb level and masculine rate of post-treatment 6 months patients were obviously higher than post-treatment24 months patients,the difference had significance( P 0. 05). The differences of serum TRAb level and masculine rate between the control group and post-treatment 24 months patients had no significance( P 0. 05). Conclusion: The Graves disease patients have fast recovery of thyroid function and the speed of serum TRAb level become normal slowly. The serum TRAb level and masculine rate have important sense in therapeutic effect judgement. The serum TRAb level will be higher than normal some time when the disease disappear. The clinical value which the serum TRAb level becoming normal is considerd the evaluation criterion of curing therapeutic effect need more approach.