The change of serum TRAb and its prognosis assess to graves disease with one-off successful 131 I therapy

To investigate dynamic change of serum receptor and antibody of thyrotrophic antibody(TRAb) and its prognosis value after a one-off successful therapy on Graves disease with 131I,257 Graves disease patients were treated with one dose of 131I therapy.175 of them with average age of 40(43 male and 132 female patients) were cured.The 131I activity given to patients was 207.2±66.6 MBq.The serum levels of TRAb were determined once every three months before and after 131I therapy.The results showed that the serum TRAb levels in all patients were positive before 131I therapy.The serum TRAb levels in 60.6% of patients were raised once,and then reduced to normal,The serum levels of TRAb in 16.0% of patients were remained high or reduce slowly,and the clinical symptom was improved slowly,but these patients didn't recrudesce.The TRAb levels in 9.7% of patients decreased continually,their prognosis was well.The TRAb levels in 13.7% of patients were raised twice after the therapy,and appear hypothyroidism.The detection of dynamic changes of serum TRAb levels in Graves disease patients may be useful in assessing prognosis after 131I therapy.