Comparative study of the efficacy of Cefepime and Ceftazidime in treating serious lower respiratory tract infections

Objective To compare the efficacy and safety of Cefepime and Ceftazidime in treating serious lower respiratory tract infections.Methods 62 patients with serious lower respiratory tract infections were selected to make randomized comparative study.28 patients in group Cefepime received 4g of Cefepime intravenously once a day,34 patients in group Ceftazidime received 4g of Ceftazidime intravenously once a day,the course of treatment was 7 to 10 days.Results The efficacy of Cefepime and Ceftazidime were 89.3% and 70.6% respectively,the difference between two groups was obvious( P 0.05).The bacterial eradication rate of two groups were 85% and 67.9%.By determining drug susceptibility we can see that bacter's sensitivity to Cefepime was higher than that to Ceftazidime,especially GPC.No adverse events occurred.Conclusion The study indicate that for the patients with serious lower respiratory tract infections,Cefepime is more safe and effective than Ceftazidime for the patients with GPC infections,Cefepime can be served as experimental drug.