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Chronopharmacokinetics study of levofloxacin in rats

Sujun Wang

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Abstract

AIM: To study the chronopharmacokinetics of levofloxacin in rats.METHODS: After levofloxacin was orally given to rats at different times,the concentrations of levofloxacin in plasma and urine were determined by HPLC and the pharmacokinetics parameters were calculated.RESULTS: The mean pharmacokinetic parameters of levofloxacin at 800,1600 and 2400 were Cmax 2.37,2.02 and 2.85 mg/L;tmax 0.56,0.50 and 0.62 h;AUC0-∞ 11.23,9.89 and 11.77 mg·h·L-1;t1/2 4.23,3.51 and 4.46 h;CLs 0.39,0.57 and 0.36 L·kg-1·h-1,respectively.The main pharmacokinetic parameters showed no significant difference by oral administration at 800,1600 and 2400.CONCLUSION: There was no obvious change in circadian rhythms of levofloxacin in rats.

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AIM: To study the chronopharmacokinetics of levofloxacin in rats.METHODS: After levofloxacin was orally given to rats at different times,the concentrations of levofloxacin in plasma and urine were determined by HPLC and the pharmacokinetics parameters were calculated.RESULTS: The mean pharmacokinetic parameters of levofloxacin at 800,1600 and 2400 were Cmax 2.37,2.02 and 2.85 mg/L;tmax 0.56,0.50 and 0.62 h;AUC0-∞ 11.23,9.89 and 11.77 mg·h·L-1;t1/2 4.23,3.51 and 4.46 h;CLs 0.39,0.57 and 0.36 L·kg-1·h-1,respectively.The main pharmacokinetic parameters showed no significant difference by oral administration at 800,1600 and 2400.CONCLUSION: There was no obvious change in circadian rhythms of levofloxacin in rats.

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Available abstract

AIM: To study the chronopharmacokinetics of levofloxacin in rats.METHODS: After levofloxacin was orally given to rats at different times,the concentrations of levofloxacin in plasma and urine were determined by HPLC and the pharmacokinetics parameters were calculated.RESULTS: The mean pharmacokinetic parameters of levofloxacin at 800,1600 and 2400 were Cmax 2.37,2.02 and 2.85 mg/L;tmax 0.56,0.50 and 0.62 h;AUC0-∞ 11.23,9.89 and 11.77 mg·h·L-1;t1/2 4.23,3.51 and 4.46 h;CLs 0.39,0.57 and 0.36 L·kg-1·h-1,respectively.The main pharmacokinetic parameters showed no significant difference by oral administration at 800,1600 and 2400.CONCLUSION: There was no obvious change in circadian rhythms of levofloxacin in rats.

Key concepts: Levofloxacin, Pharmacokinetics, Cmax, Urine, Pharmacology, CLs upper limits, Circadian rhythm, High-performance liquid chromatography

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