Pharmacokinetics of levofloxacin after a single intravenous administration in human

OBJECTIVE To study the pharmacokintics of levofloxacin in healthy Chinese volunteers after a single intraveous injection at dose of 600 mg.METHODS The plasma concentrations of levofloxacin was determined by a validated HPLC method,and pharmacokinetic parameter calculation was performed using a non-compartmental analysis.RESULTS The main pharmacokinetic parameters were as follows:Cmax was(7.5±2.1)mg·L-1;AUC0-36 was(51.1±9.8)mg·L-1·h;t1/2 was(6.8±0.7)h,Vd was(2.0±0.4)L·kg-1),λ was(0.100±0.010)h-1,MRT was(8.3±1.3)h,CL was(196.7±38.3)mL·min-1.CONCLUSION After a single intravenous injection of 600 mg of levofloxacin,the range of Cmax,t1/2 and MRT were(4.1-10.3)mg·L-1,(6.0-8.1)h,(6.6-11.0)h,respectively.Sexual differences were showed in Cmax and Vd.,but the differences were not significant after adjustment with weight.