Clinical Application of Three Steps Screening for Cervical Cancer

Objective: To evaluate the clinical application of three steps screening for cervical cancer,being thinprep cytology test(TCT),high-risk human papilloma virus(HR-HPV) DNA,and colposcopy biopsy for pathological examination.Methods:The screening results of 8 199 women who received cervical cancer screening at Chanchcheng Central Hospital of Foshan,from January 2009 to December 2011,with the three steps screening program,were analyzed retrospectively.Results:The positive rate of TCT was 6.6%,and the positive rate of ≥HSIL was 1.56%,in 8 199 participants.The infection rate of HR-HPV was 55.96% in 1 258 participants.783 participants received colposcopy,and the positive rate was 56.32%.441 patients underwent cervical biopsy,the biopsy rate was 5.38%.In pathological examination,the positive rate of precancer was 51.93%,the detection rate of high-grade cervical intraepithelial neoplasia was 25.4%.According to pathological grades,the detection rates were:CINⅠ54.70%,CINⅡ86.49%,CINⅢ96.43%,cervical cancer 97.87%.The detection rates of CINⅠand cervical cancer were higher than that of CINⅢ,while the double positive rate of TCT and HR-HPV DNA of cervical cancer was statistically higher than those of CINⅠ,CINⅡ and CINⅢ(P0.01).Conclusions: Three steps screening,TCT combining with HR-HPV DNA detection and colposcopy in cervical biopsy for pathology,can effectively detect cervical lesions and improve screening rate of cervical cancer.