Clinical analysis of 351 cases of cervical lesions diagnosed by colposcopy joint HPV-DNA

Objective:To investigate the diagnosis value and clinical significance of combined colposcopy HPV-DNA test in cervical intraepithelial neoplasia(CIN) and human papillomavirus(HPV) subclinical infection(SPI). Methods:572 cases of cervical cytology-positive patients were randomly divided into two groups,35 cases(experimental group) proceeded HPV-DNA testing of high-risk type and colposcopy image localization biopsy,221 cases(control group) only treated with traditional four-point visual cervical biopsy.For patients with high level of CIN and cervical cancer,the final diagnostic criteria depended on the surgical pathology specimens.Then,the results of two diagnostic methods were analyzed. Results:In the experimental group,the positive rate of cervical biopsy diagnosis was 52.14%,HPV-positive rate was 41.31%,and cervical biopsy missed diagnosis rate was 0.Coincident rate of diagnostic results and pathology results was 100%.While in the control group,the positive rate of cervical biopsy diagnosis was 34.39%,HPV-positive rate was 12.67%,with 71.43% coincident rate.It was mainly caused by the wrong grade cervical lesions and high cervical biopsy misdiagnosis rate 9.95%.Compared the positive rate in cervical biopsies,HPV-positive rate,diagnostic rate and misdiagnosis rate of cervical biopsy of experimental groups with control group,the difference were significant(P0.05).In the SPI comparison,the difference of positive rate between two group was significant too(P0.05). Conclusion:HPV-DNA testing combined colposcopy show a good positive predictive value,better sensitivity,and low misdiagnosis rate with high promotional value in cervical precancerous lesions,especially in low-grade cervical intraepithelial neoplasia(CIN) and human papillomavirus(HPV) subclinical infection(SPI) diagnosis.