The effect of Gengnianningxin capsule on serum FSH、LH、E_2 and symptomsin patients with female climacteric syndrome of fever due to yin-deficiency

Objective:To observe the effect of Gengnianningxin capsule on serum follicle stimulating hormone (FSH),luteinizing hormone (LH),estradiol (E 2) and clinical symptoms in patients with female climacteric syndrome of fever due to yin-deficiency.Methods:105 cases of patients with female climacteric syndrome of fever due to yin-deficiency were randomly divided into treatment group(70 cases) and control group (35 cases).Treatment group was treated by Gengnianningxin capsule,and control group was treated by Gengnianan tablet for 30 days.Levels of serum FSH,LH and E 2 were determined,meanwhile variation of symptom scores of climacteric syndrome were observed.Results:Levels of serum E 2 in the treatment group was increased significantly and levels of serum LH decreased significantly after treatment ( P 0.01).The post-treatment total symptom scores of climacteric syndrome in the treatment group were significantly improved( P 0.01).Conclusion:Gengnianningxin capsule can ameliorate significantly the levels of E 2 and LH,and clinical symptoms in patients with female climacteric syndrome of fever due to yin-deficiency.Total clinical effect of Gengnianningxin capsule is significantly better than Gengnianan tablet.