Clinical observation on changes of serum bone turnover indicators of adult females

Objective To analyze the changes of serum procollagen type Ⅰ intact N-terminal propeptide(PINP),β-Crosslaps,N-MID osteocalcin(N-MID) and parathyroid hormone(PTH) of 40-80 years old women,as well as their correlations with bone mineral density(BMD).Methods The levels of PINP,β-Crosslaps,N-MID and PTH were measured by electrochemiluminescence immunoassay;BMD was measured by American GE company's Lunar Prodigy dual energy X ray(DXA) bone density meter.Results Serum PINP,β-Crosslaps and N-MID of the 50-59 group increased significantly(P0.05),followed by slight falls;and PTH increased significantly in the 70-80 group(P0.05).PINP,β-Crosslaps and N-MID was negatively correlated with BMD of all parts(r=-0.256~-0.134,P0.05);and PTH was negatively correlated with BMD of FN and Troch(r=-0.138,-0.201,P0.05).Compared with normal group,PINP and N-MID of both low bone mass(except Ward's)and osteoporosis groups were significantly higher(P0.05);β-Crosslaps of both low bone mass and osteoporosis groups were significantly higher(P0.05).At L1-4and FN,PTH of the low bone mass group was significantly higher(P0.05),and at FN,Ward and Troch,PTH of osteoporosis group was all significantly increased(P0.05).Conclusions High bone turnover is an important cause of bone loss in women,and PINP,β-Crosslaps,N-MID and PTH are sensitive and specific bone biochemical markers which are indicators of the bone turnover change with age in women.Monitoring these indicators will help to prevent and treat osteoporosis earlier.