Clinical study of correlation between C-reactive protein and coronary heart disease

Objective:To explore the correlation between inflammation and acute coronary syndrome(ACS), stable angina pectoris(SAP), and investigate characteristics of cardiovasculat events in acute myocardial infarction(AMI) by C-reactive protein(CRP). Method:One hundred and forty-one cases were studied. ACS group includes 71 patients and was divided into AMI group (31 patients) and unstable angina pectoris (UAP group, 40 patients). There were 38 cases in normal control group. CRP concentration(mg/L) was determined by immune transmission turbidity. Result:①CRP significantly increased in ACS group compared with normal control group ( 59.64± 48.23 ∶ 4.18± 2.14,P 0.05). ②CRP was higher in AMI group compared with UAP group ( 102.23± 52.74 ∶ 28.47± 21.27,P 0.05), SAP group ( 102.23± 52.74 ∶ 6.28± 4.44 P 0.05), normal control group ( 102.23± 52.74 ∶ 4.18± 2.214,P 0.05). ③CRP in UAP group was higher compared with SAP group ( 28.47± 21.27 ∶ 6.28± 4.44,P 0.01), normal control group ( 28.47± 21.27 ∶ 4.18± 2.14,P 0.05). ④CRP in SAP group was not significantly increased compared with normal control group ( 6.28± 4.44 ∶ 4.18± 2.14,P 0.05). ⑤CRP peak occurred at 48 hours after AMI. ⑥CRP in AMI(cardiovascular events) subgroup was higher compared with one in AMI(no cardiovasculor) subgroup( 161.12± 27.19∶ 91.19± 49.23,P 0.01).Conclusion:Significant elevation of CRP suggests that inflammation occurs in ACS courses and reflects certain degree of myocardial injury and necroses. Obvious increase of CRP can predict cardiovasculor events in AMI.