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2010•Chinese Journal of Aesthetic MedicineRequires access

Influences of Th1/Th2 cytokine in vitiligo patients with 308nm excimer therapy

Huilan Yang

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Abstract

Objective To study the level of Th1 cytokine(IFN-γ) and Th2 cytokine(IL-10) in peripheral blood of patients with vitiligo,and to explore the possible immune mechanism of 308nm excimer laser for vitiligo therapy.Methods The level of IFN-γ and IL-10 in peripheral blood from 25 vitiligo patients and 20 normal control group were measured by enzyme linked immunosorbent assay.Results The level of IFN-γ were no difference in each group(P0.05).The level of IL-10 in vitiligo patients was higher than the control group(P0.05),The level of IL-10 in vitiligo patients after 308nm excimer laser therapy was higher than the control group,but the difference was not significant.Conclusion Th2 cytokine take advantage of vitiligo patients and involved in the pathogenesis of vitiligo.308nm excimer laser therapy can restore the Th1/Th2 balance.

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What this paper is about

Objective To study the level of Th1 cytokine(IFN-γ) and Th2 cytokine(IL-10) in peripheral blood of patients with vitiligo,and to explore the possible immune mechanism of 308nm excimer laser for vitiligo therapy.Methods The level of IFN-γ and IL-10 in peripheral blood from 25 vitiligo patients and 20 normal control group were measured by enzyme linked immunosorbent assay.Results The level of IFN-γ were no difference in each group(P0.05).The level of IL-10 in vitiligo patients was higher than the control group(P0.05),The level of IL-10 in vitiligo patients after 308nm excimer laser therapy was higher than the control group,but the difference was not significant.Conclusion Th2 cytokine take advantage of vitiligo patients and involved in the pathogenesis of vitiligo.308nm excimer laser therapy can restore the Th1/Th2 balance.

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Available abstract

Objective To study the level of Th1 cytokine(IFN-γ) and Th2 cytokine(IL-10) in peripheral blood of patients with vitiligo,and to explore the possible immune mechanism of 308nm excimer laser for vitiligo therapy.Methods The level of IFN-γ and IL-10 in peripheral blood from 25 vitiligo patients and 20 normal control group were measured by enzyme linked immunosorbent assay.Results The level of IFN-γ were no difference in each group(P0.05).The level of IL-10 in vitiligo patients was higher than the control group(P0.05),The level of IL-10 in vitiligo patients after 308nm excimer laser therapy was higher than the control group,but the difference was not significant.Conclusion Th2 cytokine take advantage of vitiligo patients and involved in the pathogenesis of vitiligo.308nm excimer laser therapy can restore the Th1/Th2 balance.

Key concepts: Vitiligo, Medicine, Cytokine, Pathogenesis, Immune system, Immunology, Excimer laser, Significant difference

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