Application of total intravenous anesthesia with sufentanil in thoracoscopic operation for esophageal cancer

OBJECTIVE To investigate the effect of sufentanil on anesthesia induction and recovery in thoracoscopic operation for esophageal cancer.METHODS The 40 patients scheduled for thoracoscopic operation for esophageal cancer,were randomly assigned into two groups (n=20 per group):sufentanil group and fentanyl group. Patients received midazolan (0.1 mg·kg-1),sufentanil (0.6 μg·kg-1) or fentanyl(6 μg·kg-1),propofol(2.0 mg·kg-1) and vencuronium intravenously for anesthesia induction. The anaesthesia was maintained with propofol and sufentanil (0.4 μg·kg-1·h-1) or fentanyl(4 μg·kg-1·h-1) continuous intravenous infusion. Sufentanil or fentanyl was discontinued 30 min before operation end. The propofol infusion rate was adjusted according to the value of bispectral index(BIS) and blood pressure. Sufentanil (5 μg) or fentanyl (50 μg) intravenous administration in addition if necessary during the operation. The HR,MAP and value of BIS were recorded. Conscious state was assessed using OAAS scale.RESULTS Compared with fentanyl group,patients in sufentanil group had a more stable blood pressure intraoperatively,with shorter recovery time and tracheal extubation time,and had a higher OAAS scale postoperatively.CONCLUSION Total inntravenous anesthesia with sufentanil may be suitable for long time operation as thoracoscopic operation for esophageal cancer,with hemodynamic stability and well anesthetic effect in induction and recovery.