Relation of brain natriuretic peptide and left ventricular diastolic function

Objective:To investigate the change and clinic significance of serum brain natriuretic peptide(BNP) level in patents with left ventricular(LV) diastolic dysfunction.Methods:53 patiens referred for echocardiography to evaluate the LV dysfunction.Patients with abnormal systolic function were excluded.Patients were classified as asymptomatic LV diastolic dysfunction group and symptomatic LV diastolic dysfunction group.Serum BNP concentration were measured with ELISA in 53 patients with LV diastolic dysfunction and 30 healthy persons as control group.Results:Asymptomatic and symptomatic LV diastolic dysfunction groups had higher BNP level than control group(P0.01).Patients with symptomatic LV diastolic dysfunction had higher BNP level than those with asymptomatic LV diastolic dysfunction(P0.01).Conclusions:BNP makes an useful indicator for LV diastolic function,It also is helpful to diagnosis of cardiac dysfunction.