The study of plasma brain natriuretic peptide level in patents with left ventricular diastolic dysfunction

Objective To investigate the change and clinic significance of serum brain natriuretic peptide(BNP) level in patents with left ventricular(LV) diastolic dysfunction.Methods Ninety patients referred for echocardiography to evaluate the LV dysfunction.Patients with abnormal systolic function were excluded.Patients were classified as asymptomatic LV diastolic dysfunction group and symptomatic LV diastolic dysfunction group.Serum BNP concentration were measured with ELISA in 90 patients with LV diastolic dysfunction and 50 healthy persons as control.Results Asymptomatic and symptomatic LV diastolic dysfunction groups had higher BNP level than control group(P0.01).Patients with symptomatic LV diastolic dysfunction had higher BNP level than those with asymptomatic LV diastolic dysfunction(P0.05).Conclusion BNP can be an useful indicator for LV diastolic function。 It is also helpful in the diagnosis of cardiac dysfunction.