Association between E-selectin gene polymorphism and essential hypertension in Hani minority

Objective:To investigate the association between four missense mutation in E-selectin gene including rs3917408 G/T,rs5361 A/C,rs3917429 C/T and rs5355 C/T and essential hypertension in Hani minority.Methods:E-selectin genotyped by sequence was performed in 133 normotensive subjects and 172 essential hypertensive subjects.Results:The allele frequency of the four studied polymorphism in normotensive controls and essential hypertensive cohort in Hani population were rs3917408 T:0.004vs.0.020;rs5361 C:0.049 vs 0.070;rs5368 T:0.218 vs.0.288;rs3917429 T:0.011 vs.0.061,respectively.The frequency of rs3917429 T allele in the essential hypertensive group was significantly higher than that in the normotensive controls(P0.01).No significant difference was found between the two groups in the other loci.Conclusion:The rs3917429 T allele of the E-selectin gene may play a role in genetic predisposition to developing essential hypertension in Hani minorities.