Association between E-Selectin gene rs5355C,rs3917422A polymorphism and essential Hypertension in Hani Minority

Objective To investigate the association between missense mutation in E-selectin gene including rs3917422A\C和rs5355C\T and essential hypertension in Hani minority.Methods E-selectin genotyped by sequence was performed in 172 essential hypertensive subjects and 133 normotensive subjects.Results The allele frequency of the rs5355C\T studied polymorphism in normotensive controls and essential hypertensive cohort in Hani population were 0.132vs.0.105.The frequency of rs5355C\T allele in the essential hypertensive group was not significantly higher than that in the normotensive controls(P=0.311 P0.05).No significant difference was found between the two groups.Conclusion The rs3917422A is not in the E-selectin gene and the rs5355C is in the E-selectin gene in Hani minorities.But missense mutation E-selectin gene rs5355C Polymorphism are not significantly higher than tin the normotensive controls in Hani Minority.