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2010•Zhongguo shiyan fangjixue zazhiRequires access

Comparing Dissolution of Effective Ingredients from Micro-powder and Crude Powder of Rhodiola rosea

Ding Yong-hui

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Abstract

Objective:To investigate the experimental proof for the application of super fine crushing tech-nique(SFCT) to the traditional Chinese medicinal herb and develop new methods to evaluate the effect of SFCT on drug.Method:The dissolution of Rhodiola rosea prepared by different techniques was investigated by dialysis deter-mining gallic acid,salidroside and catechin as the test marker.These markers were determined at different time by RP-HPLC.Result:The speed and degree of dissolution of salidroside and catechin were improved in micro-powder than those in crude powder after a certain time(15-45 min,P 0.05,45-60 min,P 0.01),but the difference of the gallic acid dissolution in the two kinds of powder were not obvious.Conclusion:Both the dissolution of effect component in R.rosea and the effect of Rhodiola rosea can be improved by SFCT.

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What this paper is about

Objective:To investigate the experimental proof for the application of super fine crushing tech-nique(SFCT) to the traditional Chinese medicinal herb and develop new methods to evaluate the effect of SFCT on drug.Method:The dissolution of Rhodiola rosea prepared by different techniques was investigated by dialysis deter-mining gallic acid,salidroside and catechin as the test marker.These markers were determined at different time by RP-HPLC.Result:The speed and degree of dissolution of salidroside and catechin were improved in micro-powder than those in crude powder after a certain time(15-45 min,P 0.05,45-60 min,P 0.01),but the difference of the gallic acid dissolution in the two kinds of powder were not obvious.Conclusion:Both the dissolution of effect component in R.rosea and the effect of Rhodiola rosea can be improved by SFCT.

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Available abstract

Objective:To investigate the experimental proof for the application of super fine crushing tech-nique(SFCT) to the traditional Chinese medicinal herb and develop new methods to evaluate the effect of SFCT on drug.Method:The dissolution of Rhodiola rosea prepared by different techniques was investigated by dialysis deter-mining gallic acid,salidroside and catechin as the test marker.These markers were determined at different time by RP-HPLC.Result:The speed and degree of dissolution of salidroside and catechin were improved in micro-powder than those in crude powder after a certain time(15-45 min,P 0.05,45-60 min,P 0.01),but the difference of the gallic acid dissolution in the two kinds of powder were not obvious.Conclusion:Both the dissolution of effect component in R.rosea and the effect of Rhodiola rosea can be improved by SFCT.

Key concepts: Salidroside, Rhodiola rosea, Dissolution, Rhodiola, Gallic acid, Chemistry, Chromatography, Paeonol

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Comparing Dissolution of Effective Ingredients from Micro-powder and Crude Powder of Rhodiola rosea — Research Paper | ScholarLens