Research Progress of Fetus Hypoxia Mechanism of Intrahepatic Cholestasis of Pregnancy

Intrahepatic cholestasis of pregnancy(ICP)is a cholestatic disorder characterized by pruritus with onset in the second or third trimester of pregnancy,elevated serum aminotransferases and bile acid levels,and spontaneous relief of signs and symptoms within two to three weeks after delivery.Maternal prognosis is good,but it increases the risk of preterm delivery,meconium staining of amniotic fluid,fetal distress,and fetal death.This article reviews the mechanism of fetal hypoxia in intrahepatic cholestasis of pregnancy.