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2005•Journal of Practical Medical TechniquesRequires access

Clinicopathologic Analysis of Langerhans Cell Histiocytosis of the Bone

Tao Zi-jian

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Abstract

Objective To study the clinicopathological feature of Langerhans'cell histiocytosis(LCH)of the bone.Methods A case of LCH of the bone was analyzed with light microscopic and immunohistochemical stains and related literature was reviewed.Results Histologically LCH was characterized by lesions an accumulation and/or proliferation of Langerhans cells(LCs).LCs often arrangeda diffuse pattern with a varying degree of eosinophils and focal areas exhibited a sheet or a cluster pattern.Immtmohistochemical assay showed positive S-100 protein(++) and CD_(68)(+)CD_(45).CD_(45)RO,CK(pan)were negative.Conclusion LCH is rarely lesion.Immunohistochemical study were very important for diagnosis and differential diagnosis for lesion.

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What this paper is about

Objective To study the clinicopathological feature of Langerhans'cell histiocytosis(LCH)of the bone.Methods A case of LCH of the bone was analyzed with light microscopic and immunohistochemical stains and related literature was reviewed.Results Histologically LCH was characterized by lesions an accumulation and/or proliferation of Langerhans cells(LCs).LCs often arrangeda diffuse pattern with a varying degree of eosinophils and focal areas exhibited a sheet or a cluster pattern.Immtmohistochemical assay showed positive S-100 protein(++) and CD_(68)(+)CD_(45).CD_(45)RO,CK(pan)were negative.Conclusion LCH is rarely lesion.Immunohistochemical study were very important for diagnosis and differential diagnosis for lesion.

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Available abstract

Objective To study the clinicopathological feature of Langerhans'cell histiocytosis(LCH)of the bone.Methods A case of LCH of the bone was analyzed with light microscopic and immunohistochemical stains and related literature was reviewed.Results Histologically LCH was characterized by lesions an accumulation and/or proliferation of Langerhans cells(LCs).LCs often arrangeda diffuse pattern with a varying degree of eosinophils and focal areas exhibited a sheet or a cluster pattern.Immtmohistochemical assay showed positive S-100 protein(++) and CD_(68)(+)CD_(45).CD_(45)RO,CK(pan)were negative.Conclusion LCH is rarely lesion.Immunohistochemical study were very important for diagnosis and differential diagnosis for lesion.

Key concepts: Langerhans cell histiocytosis, Medicine, Immunohistochemistry, Pathology, Lesion, Histiocytosis, Differential diagnosis, Langerhans cell

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