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2004•Academic Journal of Second Military Medical UniversityRequires access

A pathologic and immunohistochemical study on Langerhans cell histiocytosis

Hui Liu

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Abstract

Objective:To study the morphologic characteristics,the immunohenotype,the clinical features,and the dif-ferential diagnosis of bone Langerhans cell histiocytosis(LCH).Methods:Routine histopathology techniques and immunohis-tochemistry(ABC method)were used to label5antibodies(CD1a,S-100protein,CD68,P53and Ki67).Results:There were 4types of changes in25cases of LCH,including typical LC type,oval cell type,multinuclear type and larger round cell type. CD1a and S-100protein were expressed in all25cases(100%),CD68was expressed in20cases(80%),P53only expressed in 2(20%);Ki67mean index was11%.Conclusion:The expressions of CD1a and S-100protein are very important for the diag-nosis of LCH.The typical LS cells“coffee bean cells”are characteristic for the diagnosis of LCH.LCH has to be differentiat-ed from lymphoma and osteomyelitis. [

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Objective:To study the morphologic characteristics,the immunohenotype,the clinical features,and the dif-ferential diagnosis of bone Langerhans cell histiocytosis(LCH).Methods:Routine histopathology techniques and immunohis-tochemistry(ABC method)were used to label5antibodies(CD1a,S-100protein,CD68,P53and Ki67).Results:There were 4types of changes in25cases of LCH,including typical LC type,oval cell type,multinuclear type and larger round cell type. CD1a and S-100protein were expressed in all25cases(100%),CD68was expressed in20cases(80%),P53only expressed in 2(20%);Ki67mean index was11%.Conclusion:The expressions of CD1a and S-100protein are very important for the diag-nosis of LCH.The typical LS cells“coffee bean cells”are characteristic for the diagnosis of LCH.LCH has to be differentiat-ed from lymphoma and osteomyelitis. [

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Available abstract

Objective:To study the morphologic characteristics,the immunohenotype,the clinical features,and the dif-ferential diagnosis of bone Langerhans cell histiocytosis(LCH).Methods:Routine histopathology techniques and immunohis-tochemistry(ABC method)were used to label5antibodies(CD1a,S-100protein,CD68,P53and Ki67).Results:There were 4types of changes in25cases of LCH,including typical LC type,oval cell type,multinuclear type and larger round cell type. CD1a and S-100protein were expressed in all25cases(100%),CD68was expressed in20cases(80%),P53only expressed in 2(20%);Ki67mean index was11%.Conclusion:The expressions of CD1a and S-100protein are very important for the diag-nosis of LCH.The typical LS cells“coffee bean cells”are characteristic for the diagnosis of LCH.LCH has to be differentiat-ed from lymphoma and osteomyelitis. [

Key concepts: Langerhans cell histiocytosis, Histopathology, CD68, Pathology, Immunohistochemistry, Histiocytosis, Medicine, Lymphoma

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