Comparison of clinical curative effects between mosapride and domperidone in treating postprandial discomfort syndrome

Objective To compare the therapeutic effects between mosapride and domperidone in the treatment of postprandial discomfort syndrome(PDS).Methods Fifty-eight cases of PDS according to RomeⅢ PDS diagnostic criteria were randomly assigned into two groups according to admission order.In the A group,30 cases patients were treated with mosapride tablets:5 mg 3 times daily,taken before meals,in the B group,28 patients were treated with domperidone tablets:10 mg,3 times daily,taken before meals,the course were 28 days.After the end of treatment,the efficacy and adverse drug reaction were compared between two groups.Results The total effective rate in the A group was 93.3% and the total effective rate in the B group was 67.9%.There was a statistically significant difference in total effective rate between two groups( P0.05).There was minor adverse drug reactions in two groups.Conclusion The therapeutic effects of mosapride and domperidone in treating PDS are good with minor adverse reactions.But mosapride is superior to domperidone in the total effective rate.