Clinical Significiance of Serum Thymidine Kinase with Colorectal Carcinoma

Objective To investigate the diagnostic value of serum thymidine kinase 1(sTK1) in colorectal cancer.Methods The levels of sTK1 in 150 patients with colorectal cancer,36 with benign disease and 40 normal controls were determined by enhanced chemi-luminescence assay.Results The levels of sTK1 in patients with colorectal carcinoma were much higher than those in patients with benign disease and normal controls (P0.01),but there was no significant difference between patients with benign disease and normal controls(P0.05).The level of sTK1 declined significantly one month after operation.The positive rate of sTK1 in patients with colorectal cancer was much higher than other digestive tumour marker [carcinoembryonic antigen(CEA),carbohydrate antigen(CA199,CA724)].Conclusion The detection of sTK1 may have value in the diagnosis,monitoring and prognosis of colorectal cancer.