The expression and clinical significance of serum TK-1 in gastrointestinal tumors

Objective To evaluate the expression of thymidine kinase 1(STK1) in patients with gastrointestinal cancer and detection of CEA,CA199 of tumor markers,and explore its early diagnosis,clinical stage and clinical value of therapy.Methods The levels of STK1 in 150 patients with gastrointestinal tumors and 40 normal controls were determined by enhanced chemiluminescence assay.Results The density of STK1 in gastrointestinal tumors and healthy individuals had statistical significance.The sensitivity was 55%,and specificity was 87.5%,Compared with CEA and CA199,STK1 had obvious difference.Compared with separate STK1,CEA,CA199,the combined detection of STK1+CEA+CA199 increased by nearly 30%.The average density of STK1 in patients with period Ⅰ~Ⅱ and period Ⅲ~Ⅳ had obviously statistical significance.With the progress of disease,STK1 value of CR,PR,PD patients gradually increased before and after treatment.Conclusion The levels of STK1 in patients with gastrointestinal tumors were much higher than those in patients with normal control.Combined detection with CEA and CA199 can improve its positive rate.The detection of STK1 may have value in the diagnosis,monitoring and prognosis of gastrointestinal tumors.