Laboratory evaluation of endogenous glomerular filtration rate in patients with various renal diseases

Objective To evaluation of endogenous clearance marker glomerular filtration rate(GFR) in patients with various types of renal diseases.Methods We determined the serum cystatin C,urea,creatinine,and creatinine clearance levels in 57 patients with renal diseases,and 39 healthy controls,and compared the concentrations of patients with of healthy controls.Results The concentratons of serum urea,creatinine,and creatinine clearance was found to be significantly higher in the patients with renal diseases in comparison to the healthy controls(P0.01).Correlation was observed between cystatin C and creatinine clearance levels(P0.05),and between cystatin C and creatinine levels(P0.01).However,there were not correlation between creatinine and urea concentrations(P0.05),and between creatinine and creatinine clearance lenels(P0.05).Conclusion Serum cystatin C is probably more attractive for estimation of renal function than urea,creatinine,and creatinine clearance for detection of GFR in patients with early kidney diseases.