The influences of simvastatin on the anti-oxidation enzyme activity in rat and the cooperative effect of grapefruit juice and hesperidin to simvastatin

Objective To study the influences of simvastatin on the anti oxidation enzyme activity and the cooperative effect of grapefruit juice and hesperidin to simvastatin. Methods Wistar rats were divided randomly into seven groups: control group;model group; simvastatin group(SV group);low dose grapefruit juice +SV group(LDGS group);high dose grapefruit juice +SV group(HDGS group);low dose hesperidin +SV group(LDHS group) and high dose hesperidin +SV group(HDHS group).The control group was fed with a normal diet. The model group was fed with high cholesteroldiet. Other groups diet contained high lipid , 5mg/kg SV and different doses of grapefruit juice or hesperidin. After 8 weeks, the anti oxidation enzyme activity in the liver was tested in each group. Results SV can obviously enhance the anti oxidation enzyme activity of SOD、GSH Px、CAT, increase the level of GSH and decrease the level of MDA. Conclusions The grapefruit juice and hesperidin could enhance the effect on anti oxidation of SV.