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2003•Zhongguo Yike Daxue xuebaoRequires access

Expression of Matrix Metalloproteinase in Cervical Squamous Cell Carcinoma and Its Significance

Shulan Zhang

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Abstract

Objective: Our aim was to investigate the relationship between expressions of matrix metalloproteinases (MMP-2, MMP-9) and tumorigenesis, development, and invasion of cervical squamous cell carcinoma. Methods: The active proteins and mRNA of MMP-2 and MMP-9 were analyzed by using gelatin zymography and RT-PCR ,respectively, in 32 cases of cervical squamous cell carcinoma, 30 of chronic cervical inflammation, and 30 normal cervices. Results: The activities of MMP-2 and MMP-9 in carcinoma tissues were statistically higher than those in chronic cervical inflammation and normal cervices (P0.01, P0.01). mRNA of MMP-2 and MMP-9 were significantly higher in carcinoma than those in chronic cervical inflammation and normal cervices (P0.01, P0.01). Conclusion: MMP-2 and MMP-9 are related well with the occurrence, development,and invasion of cervical squamous cell carcinoma.

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What this paper is about

Objective: Our aim was to investigate the relationship between expressions of matrix metalloproteinases (MMP-2, MMP-9) and tumorigenesis, development, and invasion of cervical squamous cell carcinoma. Methods: The active proteins and mRNA of MMP-2 and MMP-9 were analyzed by using gelatin zymography and RT-PCR ,respectively, in 32 cases of cervical squamous cell carcinoma, 30 of chronic cervical inflammation, and 30 normal cervices. Results: The activities of MMP-2 and MMP-9 in carcinoma tissues were statistically higher than those in chronic cervical inflammation and normal cervices (P0.01, P0.01). mRNA of MMP-2 and MMP-9 were significantly higher in carcinoma than those in chronic cervical inflammation and normal cervices (P0.01, P0.01). Conclusion: MMP-2 and MMP-9 are related well with the occurrence, development,and invasion of cervical squamous cell carcinoma.

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Available abstract

Objective: Our aim was to investigate the relationship between expressions of matrix metalloproteinases (MMP-2, MMP-9) and tumorigenesis, development, and invasion of cervical squamous cell carcinoma. Methods: The active proteins and mRNA of MMP-2 and MMP-9 were analyzed by using gelatin zymography and RT-PCR ,respectively, in 32 cases of cervical squamous cell carcinoma, 30 of chronic cervical inflammation, and 30 normal cervices. Results: The activities of MMP-2 and MMP-9 in carcinoma tissues were statistically higher than those in chronic cervical inflammation and normal cervices (P0.01, P0.01). mRNA of MMP-2 and MMP-9 were significantly higher in carcinoma than those in chronic cervical inflammation and normal cervices (P0.01, P0.01). Conclusion: MMP-2 and MMP-9 are related well with the occurrence, development,and invasion of cervical squamous cell carcinoma.

Key concepts: Matrix metalloproteinase, Medicine, Zymography, Inflammation, Carcinogenesis, Cervical carcinoma, Pathology, Basal cell

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