Study of Expression of Matrix Metalloproteinase-9 and Tissue Metalloproteinase Inhibitor-1 in Colorectal Carcinoma with Invasion Metastasis

Objective: To explore relationship of expression of matrix metalloproteinase-9 and tissue metalloproteinase inhibitor-1 in colorectal carcinoma to invasion and metastasis. Methods: By using SP immunohistochemical method, the expression of MMP-9 and TIMP-1 were detected in 48 cases of colorectal carcinoma specimen and 23 cases of normal colorectal specimen. Results: The positive rate of MMP-9 in colorectal carcinoma was 87.5% which was higher than that in normal colorectal specimen(P 0.05); The positive rates of MMP-9 in patients with lymph node or liver metastasis were higher than that in patients with no lymph node or liver metastasis(P 0.05); The positive rates of TIMP-1 in colorectal carcinoma were 54.2% which was different with that in normal colorectal specimen(P 0.05); Lymph node and liver metastasis positive rates of the patients with the expression of MMP-9 over TIMP-1 were higher than patients with the expression of TIMP-1 over MMP-9. Conclusion: Expression unbalance of MMP-9 and TIMP-1 has a close relationship with lymph node or liver metastasis. MMP-9 promotes tumor metastasis, and TIMP-1 inhibits tumor metastasis. The patients with the expression of MMP-9 over TIMP-1 have poorer prognosis.