2006•PubMedRequires access

[Expression of tissue inhibitor of metalloproteinase-1 in colorectal carcinoma and its clinical implications].

Yang Liu, Bo Jiang, Huasheng Tong, Xiaorong Lai

Abstract

OBJECTIVE: To investigate the expression and clinical implication of tissue inhibitor of metalloproteinase-1 (TIMP-1) in colorectal carcinoma. METHODS: TIMP-1 expression in 54 colorectal carcinoma was observed by SP immunohistochemical method, and the results were analyzed in relation to the clinical data of patients. RESULTS: TIMP-1 was localized on the membrane and in the cytoplasm of the enteric epithelial cells, and its expression rate was 100% in normal tissue but only 59.6% (31/52) in colorectal carcinoma tissues. In addition, the expression rate of TIMP-1 was higher in the tumor tissues without lymph node metastasis than in tissues with lymph node metastasis (P<0.05). CONCLUSION: The expression of TIMP-1 is inversely correlated to lymph node metastasis of colorectal carcinoma, and decreased TIMP-1 expression may play a role in the progression of colorectal carcinoma.

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Key concepts: Immunohistochemistry, Colorectal cancer, Medicine, Carcinoma, Metastasis, Lymph node metastasis, Tissue inhibitor of metalloproteinase, Lymph node