EFFECTS OF EXERCISE ON MONOAMINE NEUROTRANSMITTER IN DEPRESSED RATS’ BRAIN

[Objective]To research the effects of exercises on monoamine neurotransmitters in depressed rats’ brain,and probe into the mechanism on the changes.[Methods]Selected 48 adult SD male rats. They were randomly divided into 4 groups(n = 12):control group(Group C),sports group(Group S),model group 1(Group M1),model group 2(Group M2). The rats in group C were fed with the old routine. The rats in group S received 7 weeks of normal load swimming training. The rats in group M1 and M2 received 28-day unpredictable chronic mild stress according to the literatures. After the stress finished,the rats in group M2 received 3 weeks of normal load swimming training. After the experiment,all rats were killed by decollation. Then collected samples and examined the amount of the monoamine neurotransmitter in the whole brain,the hippocampus and frontal cortex through the method of fluorescence.[Results]The results showed that the amount of monoamine neurotransmitter in the whole brain,the hippocampus and frontal cortex reduced obviously,but after swimming training,the amount of monoamine neurotransmitter increased.[Conclusion]The unpredictable chronic mild stress may reduce the amount of the monoamine neurotransmitter obviously in the whole brain,the hippocampus and frontal cortex induce the disorder of the monoaminergic systematic function. Possibly they were some of the reasons causing the depression. Normal load exercises may increase the amount of the monoamine neurotransmitter obviously in different cerebral area. It will promote the recovery of depression.