Effects of Naoshu mixture on rats' cerebrum monoamine neurotransmitter after overtraining

Objective: This research was designed to observe the effects of Naoshu mixture on rats' cerebral monoamine neurotransmitter after they had overtraining.Methods: 40 male SD rats(weight 230±20g) were divided randomly into 4 groups: control group(group C,n=10);burdened swimming group(group O,n=10);burdened swimming and low dose group(low dose group,n=10,crude drug 10g/kg);burdened swimming and high dose group(high dose group,n=10,crude drug 30g/kg).Equivalent distilled water was given to group C and group O everyday.All the groups were given increase load swimming for eight weeks,except group C.Results: The protein expression of NE in rats' cerebral cortex was reduced significantly after overtraining in group O(p0.05).But the expression of NE had no significant changes in Naoshu mixture groups.The expression of 5-H in rats' cerebral cortex had significant increase in group O(p0.05),but there was no significant change in low dose and high dose group.Conclusion: Naoshu mixture could raise the expression of NE in cerebral cortex,keep the exciting and the depressing of cerebral cortex relative balance,and maintain better function of cerebral cortex after overtraining.