Clinical Features of Primary Gastric Non-Hodgkin Lymphoma

Objective To evaluate the clinical features of primary gastric non-Hodgkin lymphoma(PG-NHL) and improve its diagnosis and clinical outcome. Methods The clinical data of 8 patients with PG-NHL were retrospectively reviewed. Results Median age of patients was 45.6(range 18～64). The clinical manifestations were abdominal pain, hematemesis, melena, nausea, vomiting, burping. Two out of eight patients were confirmed by routine endoscopic biopsy. All patients were of B-cell origin. Endoscopic findings of PG-NHL were similar to that found in gastric cancer or ulcer. PG-NHL had lighter symptoms in comparison with gastric cancer, but endoscopic appearance was more serious, and some of them showed multicentric origin which was seen frequently at gastric corpus, otherwise, there was no metastases observed in gastric cancer. Operation was able to help to confirm diagnosis and clinical stage and prevent complication. Conclusion Because of low morbidity and high false negativity in routine biopsies, PG-NHL is hard to be diagnosed. Our studies indicates that knowledge of its clinical features together with more sensitive bioptic means might be important in diagnosis and patients got beneficial from surgical management, especially for those in stages IE and ⅡE .